Elevated 5-S-cysteinyldopamine/homovanillic acid ratio and reduced homovanillic acid in cerebrospinal fluid: possible markers for and potential insights into the pathoetiology of Parkinson's disease
Identifieur interne : 002180 ( Main/Exploration ); précédent : 002179; suivant : 002181Elevated 5-S-cysteinyldopamine/homovanillic acid ratio and reduced homovanillic acid in cerebrospinal fluid: possible markers for and potential insights into the pathoetiology of Parkinson's disease
Auteurs : -C. Cheng [République populaire de Chine] ; -S. Kuo [République populaire de Chine] ; -G. Chia [République populaire de Chine] ; G. Dryhurst [États-Unis]Source :
- Journal of Neural Transmission [ 0300-9564 ] ; 1996-04-01.
Abstract
Summary: High-performance liquid chromatography with electrochemical detection has been employed to analyze ultrafiltrates of cerebrospinal fluid of Parkinson's Disease (PD) patients and age-matched controls for the dopamine (DA) metabolites homovanillic acid (HVA) and 5-S-cysteinyldopamine (5-S-CyS-DA). The mean level of HVA in the CSF of PD patients, measured 5 days after withdrawal from L-DOPA therapy, was significantly lower than that measured in controls. By contrast, mean levels of 5-S-CyS-DA were not significantly different in the CSF of PD patients taking L-DOPA (PD-LT patients) the same patients 5 days after discontinuing this drug (PD-LW patients) or controls. However, the mean 5-S-CyS-DA/HVA concentration ratio was significantly (p < 0.05) higher in the CSF of PD-LW patients compared to controls. Although the PD patient population employed in this study had been diagnosed with the disease several years previously and had been treated with L-DOPA for prolonged periods of time the results of this study suggest that low CSF levels of HVA and a high 5-S-CyS-DA/HVA ratio together might represent useful markers for early diagnosis of PD. The high 5-S-CyS-DA/HVA ratio observed in the CSF of PD-LW patients also provides support for the hypothesis that the translocation of glutathione or L-cysteine into neuromelanin-pigmented dopaminergic cell bodies in the substantia nigra might represent an early event in the pathogenesis of PD.
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DOI: 10.1007/BF01276419
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Elevated 5-S-cysteinyldopamine/homovanillic acid ratio and reduced homovanillic acid in cerebrospinal fluid: possible markers for and potential insights into the pathoetiology of Parkinson's disease</title><author><name sortKey="Cheng, C" sort="Cheng, C" uniqKey="Cheng " first="-C." last="Cheng">-C. Cheng</name></author><author><name sortKey="Kuo, S" sort="Kuo, S" uniqKey="Kuo " first="-S." last="Kuo">-S. Kuo</name></author><author><name sortKey="Chia, G" sort="Chia, G" uniqKey="Chia " first="-G." last="Chia">-G. Chia</name></author><author><name sortKey="Dryhurst, G" sort="Dryhurst, G" uniqKey="Dryhurst G" first="G." last="Dryhurst">G. Dryhurst</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:E090C93240019A137A7B06433CAF5FBC90AEA99B</idno><date when="1996" year="1996">1996</date><idno type="doi">10.1007/BF01276419</idno><idno type="url">https://api.istex.fr/document/E090C93240019A137A7B06433CAF5FBC90AEA99B/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">001F63</idno><idno type="wicri:Area/Main/Curation">001C69</idno><idno type="wicri:Area/Main/Exploration">002180</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Elevated 5-S-cysteinyldopamine/homovanillic acid ratio and reduced homovanillic acid in cerebrospinal fluid: possible markers for and potential insights into the pathoetiology of Parkinson's disease</title><author><name sortKey="Cheng, C" sort="Cheng, C" uniqKey="Cheng " first="-C." last="Cheng">-C. Cheng</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Research and Geriatrics Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Kuo, S" sort="Kuo, S" uniqKey="Kuo " first="-S." last="Kuo">-S. Kuo</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Medical Research and Geriatrics Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Chia, G" sort="Chia, G" uniqKey="Chia " first="-G." last="Chia">-G. Chia</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Section of Neurology, Taichung Veterans General Hospital, Taichung, Taiwan</wicri:regionArea><wicri:noRegion>Taiwan</wicri:noRegion></affiliation></author><author><name sortKey="Dryhurst, G" sort="Dryhurst, G" uniqKey="Dryhurst G" first="G." last="Dryhurst">G. Dryhurst</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK</wicri:regionArea><placeName><region type="state">Oklahoma</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Neural Transmission</title><title level="j" type="sub">Basic neurosciences and genetics, Parkinson's disease and allied conditions, Alzheimer's disease and related disorders, biological psychiatry</title><title level="j" type="abbrev">J. Neural Transmission</title><idno type="ISSN">0300-9564</idno><idno type="eISSN">1435-1463</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Vienna</pubPlace><date type="published" when="1996-04-01">1996-04-01</date><biblScope unit="volume">103</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="433">433</biblScope><biblScope unit="page" to="446">446</biblScope></imprint><idno type="ISSN">0300-9564</idno></series><idno type="istex">E090C93240019A137A7B06433CAF5FBC90AEA99B</idno><idno type="DOI">10.1007/BF01276419</idno><idno type="ArticleID">Art5</idno><idno type="ArticleID">BF01276419</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0300-9564</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Summary: High-performance liquid chromatography with electrochemical detection has been employed to analyze ultrafiltrates of cerebrospinal fluid of Parkinson's Disease (PD) patients and age-matched controls for the dopamine (DA) metabolites homovanillic acid (HVA) and 5-S-cysteinyldopamine (5-S-CyS-DA). The mean level of HVA in the CSF of PD patients, measured 5 days after withdrawal from L-DOPA therapy, was significantly lower than that measured in controls. By contrast, mean levels of 5-S-CyS-DA were not significantly different in the CSF of PD patients taking L-DOPA (PD-LT patients) the same patients 5 days after discontinuing this drug (PD-LW patients) or controls. However, the mean 5-S-CyS-DA/HVA concentration ratio was significantly (p < 0.05) higher in the CSF of PD-LW patients compared to controls. Although the PD patient population employed in this study had been diagnosed with the disease several years previously and had been treated with L-DOPA for prolonged periods of time the results of this study suggest that low CSF levels of HVA and a high 5-S-CyS-DA/HVA ratio together might represent useful markers for early diagnosis of PD. The high 5-S-CyS-DA/HVA ratio observed in the CSF of PD-LW patients also provides support for the hypothesis that the translocation of glutathione or L-cysteine into neuromelanin-pigmented dopaminergic cell bodies in the substantia nigra might represent an early event in the pathogenesis of PD.</div></front></TEI><affiliations><list><country><li>République populaire de Chine</li><li>États-Unis</li></country><region><li>Oklahoma</li></region></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Cheng, C" sort="Cheng, C" uniqKey="Cheng " first="-C." last="Cheng">-C. Cheng</name></noRegion><name sortKey="Chia, G" sort="Chia, G" uniqKey="Chia " first="-G." last="Chia">-G. Chia</name><name sortKey="Kuo, S" sort="Kuo, S" uniqKey="Kuo " first="-S." last="Kuo">-S. Kuo</name></country><country name="États-Unis"><region name="Oklahoma"><name sortKey="Dryhurst, G" sort="Dryhurst, G" uniqKey="Dryhurst G" first="G." last="Dryhurst">G. 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